澳门威尼斯app下载

医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是澳门威尼斯app下载六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759364
中国科学院院士: 邓子新、舒红兵
国家级教学名师: 樊明文、边专
国家杰出青年基金获得者: 邓子新、舒红兵、章晓联、李红良、卿国良
百千万人才工程选者: 舒红兵、黄从新、章晓联?
万人计划: 领军人才:舒红兵、唐其柱、李红良 ? ? ?
教育部新世纪优秀人才: 章晓联、何小华、乐江、 于红刚 、 李雁、郑芳、
胡锦跃、 黄鹤、李红良、 张 旗、 叶晓茜、 尚政军、 郭继华、 张玉峰、
周海兵、 刘天罡、 王连荣、 瞿旭东、洪 葵

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姓名:章晓联

单位:澳门威尼斯app下载基础医学院免疫学系,湖北省过敏及免疫相关疾病重点实验室

职称:系主任及重点实验室主任、教授、博导

邮箱:zhangxiaolian@whu.edu.cn

联系电话:027-68750067

研究方向:

1.糖基化修饰与免疫:主要关注和揭示糖基化修饰、糖苷和凝集素在感染、肿瘤免疫识别和逃逸中的关键功能。

2.感染免疫:人类重要病原微生物(丙肝、结核等)慢性感染、致病及免疫逃逸机制研究;设计和研制了特异结合这些病原微生物/肿瘤细胞表面糖苷的药物分子、糖基化抑制剂、有效诊断试剂和疫苗。












代表性论著:

1.Wang SR, Min YQ, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T, Zhang XL*, Zhou X*. (2016) A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2(4): e1501535.

2.Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. (2016) A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against Tuberculosis. J Am Chem Soc. 138(36):11680-9.

3.Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.

4. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96.

5.Xiang T, Yang G, Liu X, Zhou Y, Fu Z, Lu F, Gu J, Taniguchi N, Tan Z, Chen X, Xie Y, Guan F, Zhang XL*. (2017) Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. Biochim Biophys Acta. 861(5 Pt A):1036-1045.

6.Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN, Li HL, Zhang XL*.(2017) FCN-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology Apr 5. doi: 10.1111/imm.12741.

7.Qian XJ#, Zhang XL#, Zhao P, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Zhu YZ, Qi ZT. (2016) A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. Sci Rep. 6:27268.

8.Tang XL, Wu SM, Xie Y, Song N, Guan Q, Yuan C, Zhou X, Zhang XL*. (2016) Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis. J Infect, 72(5):573-586.

9.Ren Y, Min YQ, Liu M, Chi L, Zhao P, Zhang XL*.(2016) N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim Biophys Acta, 1860(8): 1764-1775.

10.Luo W, Qu ZL, Xie Y, Xiang J, Zhang XL*. (2015) Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect, 71(5):534-543.

11.Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. (2014) CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect, 69: 569-580.

12.Tang XL, Yuan CH, Ding QQ, Zhou YD, Pan Q, Zhang XL*. (2017) Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection. Tuberculosis (Edinb), 104: 95-106.

13.Pan Q, Yan J, Liu Q, Yuan C, Zhang XL*. (2017) An ssDNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression. Microbiol Immunol. 2017, 61: 92-102.

14.Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang XL*. (2016) Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016 Oct;31(5):406-414.

15.Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F, Zhang XL*. (2015) Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin, 2015, 30(4):249-60.

16.Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, and Zhou X*. (2015) Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 134:30-36.

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教育部 国家卫生健康委员会 省教育厅 省卫生健康委 澳门威尼斯app下载 校图书馆
基础医学院 第一临床学院(人民医院) 第二临床学院(中南医院) 口腔医学院(口腔医院) 药学院 健康学院 医学研究院 医学职业技术学院 动物实验中心和ABSL-Ⅲ实验室 亚心临床学院(亚洲心脏病医院) 同仁临床学院(同仁医院) 武汉总医院临床学院(广州军区武汉总医院) 恩施临床学院(恩施州中心医院) 医学部附属中山医院
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